Farnese, Alessandro, Duke of Parma.

reporting his campaign against the Dutch rebels, assuring Sixtus that he is sparing no effort or time in suppressing them, despite the number of their German allies, and asking him to appoint his [fourteen-year-old] son Odoardo as Cardinal Farnese, in place of his uncle [Alessandro Farnese] ("...non solo di admetter le renuntie che li pensa fare il Cardinale Farnese mi Zio, mà di persuadere al detto Cardinale con l'autorita sua ad abbrevarlo, honorando la persona di mio fig[li]^{o..."), explaining that it would signal to Italy and the whole world that his efforts in the Netherlands meet with papal favour and esteem, thanking him effusively for his letter of 2 August, 3 pages, folio (33.5 x 21.5cms), the address leaf annotated for the recipient, military camp "appresso a Buorich" (ie Buer, near Bochum), 22 September 1586, 2 small holes, affecting 1 or 2 words on the second page, light overall browning} 

Condition is described in the main body of the cataloguing, where appropriate
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Alessandro led the Catholic forces in the Spanish Netherlands, where he served Philip II of Spain as Governor from 1578 until his death in 1592. His uncle, also Alessandro Farnese (1520-1589), whom our Alessandro here urges the Pope to replace as cardinal with his own son, was the great collector of Roman antiquities, who features in Titian's celebrated portrait of Pope Paul III with his two grandsons. Odoardo was duly made cardinal in 1591, but only after the deaths of both cardinal and pope.  

"hora mi trovo sull' Reno per finir di servarlo, e giuntamente la villa di Berchen, non havendo potuto così brevemente, como harei desiderato venirne a fine per i mali tempi, per li 'infermita che son corse nell' esercito, e anco perche m'è convenuto stare alla mira di quello, che facevano i nemici di Dio, et rebbelli dell' Re mio sig.re, con la gente che aspettavano di alemagna in assai grosso numero...la supplico di nuovo resti servita non solo di admetter le renuntie che li pensa fare il Cardinale Farnese mi Zio,mà di persuadere al detto Cardinale con l'atorita sua ad abbrevarlo, honorando la persona di mio fig[li]o...