The subject derives from the famous lost composition of Leda by Leonardo da Vinci, which influenced and inspired a number of Netherlandish artists of the period including Joos van Cleve and Cornelis van Cleve, both of whom painted variants on the subject. Sellaer was exposed to Italian painting during his sojourn in Brescia around 1522–24, where he is thought to have worked with the painter Moretto da Brescia.
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