- A Prospect of exterminating the Small Pox Part II, A Continuation of a Narrative of Facts concerning the Progress of the new Innoculation in America. Cambridge, Massachusetts: William Hilliard at the University Press, for the Author, 1802
Waterhouse was the first to use the Jennerian vaccination for smallpox in the United States, procuring some cowpox vaccine from England and vaccinating his five-year-old son and a servant boy. Six weeks after the initial experiment, Waterhouse published the first part of his report (1800). The second part, offered here, details his study of the first two years of vaccination in America.
Samuel Latham Mitchill (1764-1831) was one of the first American physicians to accept Jenner's ideas, publishing Jenner's account of his research in the journal, Medical Repository. Waterhouse also sent a copy to Thomas Jefferson a year later (1 March 1803), who became an ardent supporter of the vaccination cause.