Minot, George R. & William P. Murphy

"Treatment of pernicious anemia by a special diet." Offprint from the Journal of the American Medical Association, vol. 87. Chicago: American Medical Association, 1926)



8vo (8 1/2 x 5 1/2 in.; 215 x 140 mm). One text diagram. Original gray-green printed wrappers, in a black cloth slipcase with typed title label on spine.

Norman 1516

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First edition, offprint issue in gray-green wrappers, inscribed by Minot: "For M. Evans with regards Sept 16 1936 from George R. Minot. This is the first paper on liver therapy in P.A., which in these past 10 years has [been] of interest apparently to many men. G.R.M." and on the first page of text: "First presented early May 1936 [sic] before the Association of American Physicians at Atlantic City N.J. but publicly alluded to a few days before in brief fashion at a meeting at the Boston Medical Library. G.R.M."

Minot and Murphy's work demonstrated that pernicious anemia is a deficiency disease caused by the lack of a nutrient which was identified in 1948 as vitamin B12. For this work they were awarded the Nobel Prize for Medicine in 1934.